Reversing Splenomegalies in Epstein Barr Virus Infected Children: Mechanisms of Toxicity in Viral Diseases
نویسنده
چکیده
Abstract The rapid reversal of splenomegaly in Epstein Barr Virus EBV infected children and young adults was seen in over 50 patients treated with a combination therapy that reduced reactive oxygen species, increased interferon gamma and decreased free nitric oxide in lymphocytes. The patients showed dramatic improvement within 24 hours with successful remission of the disease and complete reversal of splenomegalies. Abbreviations:EBV = Epstein Barr Virus; eNOS= endothelial nitric oxide synthase; iNOS=inducible nitric oxide synthase; NO = Nitric oxide; ROS = reactive oxygen species; XO = Xanthine oxidase
منابع مشابه
The relationship between Human Papillomavirus and Epstein-Barr virus infections with breast cancer of Iranian patients
Background: Breast cancer is the malignancy in humans and other mammals. Several risk factors are involved in their appearance such as higher hormone levels and obesity. Identification of a mouse mammary tumor virus supports a viral etiology for breast tumors in animals. Viruses have been implicated in the development of various cancers, but viral induction for formation breast cancer is contro...
متن کاملExpression of Epstein-Barr virus in Hodgkin lymphoma Specimens in IRAN.
Background & Objectives: The Epstein-Barr Virus (EBV( is related with various diseases including infectious mononucleosis, Burkitt's lymphoma, Hodgkin's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoprolifrative disorders. The aim of this study was to characterize the association between EBV and Hodgkin's lymphoma through EBERs in situ hybridization (EBER-ISH) in Iranian pat...
متن کاملDiagnosis of viral myocarditis in children by multiplex real-time PCR in Vali-Asr Hospital, Birjand, eastern Iran
Background and Objective: Viral myocarditis (VMC) is one of the common heart diseases to endanger human health in different age groups, especially children. The aim of this study was to diagnose VMC in children with clinical suspicion of myocarditis (MCI) using multiplex real-time PCR in Birjand Vali-Asr Hospital. Methods: This cross-sectional study was conducted on 19 patients with clinical s...
متن کاملDistribution of Epstein-Barr Virus and Human Herpesvirus 8 Co-Infections among Human Immunodeficiency Virus -1 Positive Patients
Background and Aims: Among Human Immunodeficiency Virus (HIV)-infected individuals, Epstein-Barr virus (EBV) and Human Herpesvirus (HHV)-8 could cause significant illness as opportunistic infections. The purpose of the present study was to evaluate the prevalence of EBV and HHV-8 in saliva specimens obtained from HIV-1 infected Iranian individuals under the Highly Active Antiviral Therapy (HAAR...
متن کاملResponse to valacyclovir in an HIV-infected girl with Epstein Barr infection.
Response of EBV infection to valacyclovir in HIV infected children has not been reported earlier. An 8 years old HIV infected girl with undetectable viral load and normal CD4 count on regular antiretroviral therapy presented with persistent fever, lymphadenopathy and pancytopenia due to Epstein Barr virus (EBV). The child responded to valacyclovir.
متن کامل